{"id":76,"date":"2016-03-07T20:24:09","date_gmt":"2016-03-07T20:24:09","guid":{"rendered":"http:\/\/www.lifestyle.victoriamedia.net\/health\/?p=76"},"modified":"2016-03-07T20:25:33","modified_gmt":"2016-03-07T20:25:33","slug":"avoiding-peanut-after-building-tolerance-is-safe-for-children","status":"publish","type":"post","link":"https:\/\/www.lifestyle.victoriamedia.net\/health\/avoiding-peanut-after-building-tolerance-is-safe-for-children\/","title":{"rendered":"Avoiding peanut after building tolerance is safe for children"},"content":{"rendered":"<p>The Immune Tolerance Network\u2019s (ITN) LEAP-ON clinical trial has found that peanut allergy prevention achieved from early peanut consumption in at-risk infants persists after a one-year period of avoiding peanut. LEAP-ON (Persistence of Oral Tolerance to Peanut) was led by Dr. Gideon Lack from Kings College London and the results were published today in the <a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1514209\" target=\"_blank\"><em>New England Journal of Medicine<\/em><\/a>.<\/p>\n<p>The LEAP-ON study was an extension of the ITN\u2019s landmark <a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1414850\" target=\"_blank\">LEAP Study<\/a> (Learning Early About Peanut Allergy), which demonstrated that regular peanut consumption begun in early infancy and continued until age 5 reduced the rate of peanut allergy in at-risk infants by 80% compared to non-peanut-consumers. LEAP was the first large, well-controlled study to conclusively show the benefits of early peanut consumption in this population, changing previous notions about peanut allergy prevention.<\/p>\n<p>LEAP-ON examined the question of whether participants who had consumed peanut for more than four years were protected long-term against peanut allergy when they stopped eating peanut. The study followed 556 of the original 640 children in LEAP (both consumers and avoiders) for a one-year period of peanut avoidance. This cohort included 274 previous peanut consumers and 282 previous peanut avoiders.<\/p>\n<p>After 12 months of peanut avoidance, only 4.8% of the original peanut consumers were found to be allergic, compared to 18.6% of the original peanut avoiders, a highly significant difference.<\/p>\n<p>\u201cThe LEAP-ON findings exceeded our expectations and demonstrated\u00a0that the early consumption of peanuts provided stable and sustained protection against the development of peanut allergy in children at greatest risk for this allergy,\u201d Dr. Lack pointed out. \u201cThis protective effect occurred irrespective of whether the children completely avoided peanut for one year or continued to eat it sporadically.\u201d<\/p>\n<p>The persistence of tolerance with complete avoidance of peanut for one year strongly suggests that periodic lapses in peanut consumption will not cause a reemergence of allergy.<\/p>\n<p>\u201cThis study offers reassurance that eating peanut-containing foods as part of a normal diet\u2014with occasional periods of time without peanut\u2014will be a safe practice for most children following successful tolerance therapy,\u201d said <a href=\"http:\/\/www.immunetolerance.org\/professionals\/staff\/gerald-t-nepom\">Dr. Gerald Nepom<\/a>, Director of the Immune Tolerance Network. \u201cThe immune system appears to remember and sustain its tolerant state, even without continuous regular exposure to peanuts.\u201d<\/p>\n<p>Datasets and figures from both the LEAP and LEAP-ON published manuscripts (including de-identified participant-level data) are available to the public on the ITN\u2019s clinical research portal, <a href=\"https:\/\/www.itntrialshare.org\/\" target=\"_blank\">TrialShare<\/a>. The community is encouraged to use this rich data resource to perform novel exploratory analyses and generate new hypotheses about peanut allergy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Immune Tolerance Network\u2019s (ITN) LEAP-ON clinical trial has found that peanut allergy prevention achieved from early peanut consumption in at-risk infants persists after a one-year period of avoiding peanut. LEAP-ON (Persistence of Oral Tolerance to Peanut) was led by Dr. Gideon Lack from Kings College London and the results were published today in the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":77,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-76","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-asthma-and-allergies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Avoiding peanut after building tolerance is safe for children - VICTORIA MEDIA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lifestyle.victoriamedia.net\/health\/avoiding-peanut-after-building-tolerance-is-safe-for-children\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Avoiding peanut after building tolerance is safe for children - VICTORIA MEDIA\" \/>\n<meta property=\"og:description\" content=\"The Immune Tolerance Network\u2019s (ITN) LEAP-ON clinical trial has found that peanut allergy prevention achieved from early peanut consumption in at-risk infants persists after a one-year period of avoiding peanut. 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